Dear Reader,
Nitric Oxide plays an essential role in keeping the human body healthy in many ways.
It can help in the treatment of a variety of conditions and ailments that we humans are faced with throughout our lives.
Nitric Oxide Booster Supplements are also used in the health and fitness industry by bodybuilders, athletes and ordinary people looking to go that extra mile while working out, as nitric oxide increases the flow of blood through the body, which in turn leads to a quicker recovery time for your muscles, which facilitates greater strength and endurance.
This Blog aims to explain some of the ways that the body uses nitric oxide. However, because of the amount of technical terms and confusing scientific language used to explain the benefits of nitric oxide, I will seek to explain wherever possible the meaning of some of the terms used, to help you gain a better understanding of what is being said on the subject matter.
In the first instance the title of this report warrants explanation of the words Renin and Vasopressin:
- Renin – is a protein digesting enzyme produced in the kidneys that controls the activation of the hormone angiotensin, which stimulates the adrenal glands to produce aldosterone.
- Vasopressin - is a relatively small (peptide) molecule that is released by the pituitary gland at the base of the brain after being made nearby (in the hypothalamus.
Investigation during the intervening years has established nitric oxide to be a unique signalling molecule that performs very important functions in the regulation of the cardiovascular, nervous, immune, and other systems within the body.
Nitric Oxide has also been implicated in the control of the emission of hormones by the pancreas, hypothalamus, and anterior pituitary gland, and evidence is growing
that it helps to support the regulation of the secretion of renin and vasopressin
hormones that play key roles in the control of sodium and water balance.
Numerous lines of verification have concluded that nitric oxide helps in the control of renin secretion.
The enzyme nitric oxide synthase is present in vascular and tubular elements of the kidney, chiefly in cells of the macula densa, a structure that performs an indispensable function in the control of renin secretion.
The enzyme Guanylyl cyclase, which is a major target for nitric oxide, also resides in the kidney.
Drugs that restrain nitric oxide synthesis generally suppress renin release in vivo and in vitro, suggesting a stimulatory function for the L-arginine/nitric oxide pathway in the control of renin secretion.
Under certain conditions, however, an obstruction of nitric oxide synthesis increases renin secretion.
Latest studies show that nitric oxide not only helps in the regulation of basal renin secretion, but it also partakes in the renin secretory responses to set in motion the renal baroreceptor (sensors located in the blood vessels) macula densa, and beta adrenoceptor mechanisms that regulate renin secretion.
Histochemical and immunocytochemical research have shown that they contain nitric oxide synthase in the supraoptic and paraventricular nuclei of the hypothalamus and in the posterior pituitary gland.
Observation of nitric oxide synthase and vasopressin have concluded that it is also present in some hypothalamic neurons.
The activity of nitric oxide synthase in the hypothalamus and pituitary is increased by manoeuvres known to encourage vasopressin secretion, including salt loading and dehydration.
Administration of L-arginine and nitric oxide donors in vitro and in vivo has variable effects on vasopressin secretion, but the most common one is inhibition.
Obstruction of nitric oxide synthesis has been reported to increase vasopressin secretion, but only unpredictable findings have been obtained.
A popular working theory is that nitric oxide serves a neuromodulatory function in vasopressin secretion.
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